Haemophilia is a blood disorder that prevents blood from clotting properly, leading to uncontrolled bleeding. Haemophilia is actually a combination of different genetic disorders passed on by heredity. Bleeding is common into joints such as knees, ankles and elbows. This may be caused by injury, but in severe haemophilia, can begin spontaneously. Less commonly, bleeding into muscles or internal organs can occur.The two most common types are haemophilia A and haemophilia B.
Two main varieties of haemophilia exist. Haemophilia A is responsible for eighty percent of all cases. The genetic disorders responsible for haemophilia A result in low levels or abnormal production of the clotting protein factor VIII (FVIII). Haemophilia B, the second most common form of haemophilia, affects factor IX proteins (FIX) and accounts for almost twenty percent of haemophilia cases.
Other hereditary haemophilia disorders may affect other blood clotting factors, but they occur rarely. The most common of these rare disorders, haemophilia C, only occurs in 1 out of every 100,000 births. However, the condition is more common in the Ashkenazi Jewish community. Haemophilia C affects factor XI proteins and is unusual in that it affects both males and females.
Other sources of information for these topics.
UK Haemophilia Society
Working to secure the best possible care, treatment and support for people with haemophilia, related bleeding disorders, and their families.
Haemophilia Home Page
Haemophilia: journal information, contents lists and abstracts on the Blackwell Publishing website.
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